Research

Research Summary:Aging of skin is an intricate biological process consisting of two types. While intrinsic or chronological aging is an inevitable process, photoaging involves the premature aging of skin occurring due to cumulative exposure to ultraviolet radiation. Chronological and photoaging both have clinically differentiable manifestations. Various natural and synthetic retinoids have been explored for the treatment of aging, and many of them have shown histological and clinical improvement. However, most of the studies have been carried out in patients presenting with photoaged skin. Among the retinoids, tretinoin is possibly the most potent and certainly the most widely investigated retinoid for...

Research Summary: Nature is full of various nanomaterials and nanostructures that have inspired and helped human life and civilization in the advancement of science and technology. Among these materials are clays, which are abundantly found in rocks and earth structures. The mineral montmorillonite, known as a clay nanoparticle, is the major phase in bentonite. This nanoclay, with a thickness of about 10 angstroms, includes unique properties such as expansion, high specific surface area, and electrical properties. It also has a high cation exchange capacity and has found numerous applications in industry and research. Among its uses are its role as...

Research Summary:Omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) are desirable components of oils with special dietary and functional properties. Their therapeutic and health-promoting effects have already been established in various chronic inflammatory and autoimmune diseases through mechanisms such as modifications in cell membrane lipid composition, gene expression, cellular metabolism, and signal transduction. The application of ω-3 and ω-6 PUFAs in common skin diseases has been examined in numerous studies, but the results and conclusions were often opposing and inconclusive. It seems that a combination of ω-6, gamma-linolenic acid (GLA), and ω-3 long-chain PUFAs supplementation exhibits the highest potential...

Research Summary: Niacinamide, also known as vitamin B3, is an essential nutrient that, once inside the body, is converted into the co-factors NADH and NADPH. These co-factors are involved in numerous biochemical reactions. A deficiency of this water-soluble vitamin, a member of the vitamin B family, causes pellagra, a disease characterized by dermatitis and red lesions. Pellagra led to thousands of deaths in the United States during the first half of the 20th century until dietary supplementation with niacinamide was found to cure the condition.As we age, NAD+ and NADPH levels in skin cells decline. Therefore, supplementing the skin with...