Research — vitamins

Research Summary: The last two decades have seen an increase in active-led skin care products in over-the-counter and retail marketplaces. Consumers have become more knowledgeable about the ingredients used in topical products, resulting in formulations with vitamins and other active ingredients gaining popularity. Further, with the need for instantaneous and short-term benefits, consumers are moving towards high doses of active products. This poses a challenge for formulation scientists to stabilize high active doses and ensure potency over the shelf life. Vitamin C, or ascorbic acid, is one such ubiquitous active commonly found in topical products claiming brightening, skin firming, and...

Research Summary:Background: Vitamin C is a micronutrient present in high concentrations in normal skin and is a highly prescribed cosmeceutical known for its protective effects against ultraviolet-induced pigmentation and its role in regulating collagen production. However, there is a lack of studies evaluating the efficacy of topical vitamin C in photoaging and melasma, making this systematic review the first to assess the existing evidence.Aim: This systematic review aims to evaluate whether topical vitamin C could be effective in reversing signs of photoaging and treating melasma.Methods: Prospective, randomized controlled trials that assessed protocols involving topically applied vitamin C in patients with...

Research Summary: Humans are exposed to various external environmental factors, with food intake being one of the most influential factors impacting daily lifestyle. Among the nutrients obtained from foods, omega-3 polyunsaturated fatty acids (PUFAs) have been shown to have various beneficial effects on inflammatory diseases. Furthermore, omega-3 PUFA metabolites, including resolvins, are known to exhibit strong anti-inflammatory effects during allergic and inflammatory diseases. However, little is known about the actual impact of these metabolites on skin diseases.In this review, we focused on metabolites that have strong anti-inflammatory actions in various inflammatory diseases, as well as those that present antitumor actions...

Research Summary: Niacinamide, an amide of vitamin B3 (niacin), is a hydrophilic endogenous substance. Its effects after epicutaneous application have long been described in the literature. Given sufficient bioavailability, niacinamide exhibits antipruritic, antimicrobial, vasoactive, photo-protective, sebostatic, and lightening effects depending on its concentration.Within a complex metabolic system, niacinamide controls the NFκB-mediated transcription of signaling molecules by inhibiting the nuclear poly (ADP-ribose) polymerase-1 (PARP-1). Niacinamide is a well-tolerated and safe substance often used in cosmetics. Clinical data for its therapeutic use in various dermatoses can increasingly be found in the literature. Although the existing data are not sufficient for a scientifically...