Research — microbiome

Research Summary: The skin is a vital organ, serving as the body’s largest barrier, but its function declines with aging. As a result, research into effective regeneration treatments must continue to advance. Stem cell transplantation, a cell-based therapy, has become a popular treatment for skin aging, although it comes with drawbacks such as host immune reactions. To address this, stem cell-derived cell-free therapies have emerged as an alternative, backed by promising preclinical findings. The key components in cell-free therapy from stem cells are stem cell secretomes and extracellular vesicles (EVs). However, comprehensive reviews on the mechanisms of such treatments for...

Research Summary: Niacinamide, an amide of vitamin B3 (niacin), is a hydrophilic endogenous substance. Its effects after epicutaneous application have long been described in the literature. Given sufficient bioavailability, niacinamide exhibits antipruritic, antimicrobial, vasoactive, photo-protective, sebostatic, and lightening effects depending on its concentration.Within a complex metabolic system, niacinamide controls the NFκB-mediated transcription of signaling molecules by inhibiting the nuclear poly (ADP-ribose) polymerase-1 (PARP-1). Niacinamide is a well-tolerated and safe substance often used in cosmetics. Clinical data for its therapeutic use in various dermatoses can increasingly be found in the literature. Although the existing data are not sufficient for a scientifically...

Research Summary: α-(-)-bisabolol, a natural monocyclic sesquiterpene found in essential oils, has garnered significant interest in the chemical and pharmaceutical industries and is currently utilized in various formulations, particularly in cosmetics. This study aimed to evaluate its therapeutic potential against skin inflammation using in-vitro, in-vivo, and in-silico assays.Lipopolysaccharide (LPS) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced production of pro-inflammatory cytokines (TNF-α and IL-6) in macrophage cells, as well as TPA-induced skin inflammation in mice, were significantly inhibited by α-(-)-bisabolol. Furthermore, TPA-induced ear thickness, ear weight, lipid peroxidation, and histopathological damage in ear tissue were also significantly reduced by the topical application of α-(-)-bisabolol in...

Research Summary: In recent decades, there has been a rising demand for anti-aging interventions aimed at postponing or potentially reversing indicators of skin aging. The use of collagen-based nutraceutical supplements has gained popularity as they have shown promise in enhancing skin health and reducing signs of aging. The aim of this randomized, placebo-controlled, blinded study was to investigate the effects of 2.5 g COLLinstant® LMW, a novel cosmeceutical containing low molecular weight (≤ 1000 Da) collagen peptides, on skin aging and health. The trial was conducted in 80 healthy women aged 30 years and older. They received a daily oral...