Research

Research Summary Ubiquinone (coenzyme Q10, Q10) is an endogenously synthesized lipid-soluble antioxidant that plays a crucial role in cellular energy production. However, its levels diminish with age and under the influence of external stress factors in human skin. This study demonstrates that topical Q10 treatment is beneficial for effective Q10 replenishment, augmentation of cellular energy metabolism, and antioxidant effects.The application of Q10-containing formulas significantly increased the levels of this quinone on the skin surface. Notably, in the deeper layers of the epidermis, the ubiquinone level was significantly augmented, indicating effective supplementation. The concurrent elevation of ubiquinol levels suggested a metabolic...

Research Summary Emollient oils are ubiquitous ingredients in personal care products, especially in skin care and hair care formulations. They offer excellent spreading properties and provide end-use products with a soft, pleasant, and non-sticky after-feel. Emollients come from various petro- or bio-based chemical families, with silicone oils, hydrocarbons, and esters being the most prominent. Silicones possess exceptional physicochemical and sensory properties, but their high chemical stability results in very low biodegradability and a high bioaccumulation potential.Nowadays, consumers are increasingly conscious of environmental issues and demand more environmentally friendly products. This awareness strongly encourages the cosmetics industry to develop bio-based alternatives...

Research Summary  Premature skin aging results from exposure to a range of environmental factors, primarily ultraviolet radiation, but also high-energy visible light in the blue spectrum, infrared radiation, and environmental pollution. These extrinsic factors lead to the generation of reactive oxygen species, promoting photoaging and DNA damage, which may result in skin cancers.Aims: This study aimed to formulate skincare products utilizing a new coating applied to zinc oxide and titanium dioxide particles, along with complementary skincare ingredients, to provide broad protection against various environmental insults.Methods: A cross-polymer, multifunctional coating of silicate, polyalkylsilsesquioxane, and polydimethylsiloxane moieties was used to increase the...

Research Summary Skin aging goes beyond a chronological process and is also influenced by extrinsic factors referred to as the exposome. Hyaluronic acid (HA), an important component of the extracellular matrix, begins to decrease in the body starting at the age of 25. While many studies focus on the topical use of HA, few literature reviews address its specific role in dermatology. This review highlights the characteristics of HA-containing cosmeceuticals, with a particular focus on skin aging and the impact of exposome factors on HA synthesis and degradation.A review was conducted using search terms such as HA, hyaluronan, topical, dermatology,...