nouvelles-1 — Ingredients

Research Summary: This study investigated the effects of a skin protectant solution (dimethicone 2%) on clinical signs and skin barrier function in canine atopic dermatitis (AD). Eighteen dogs with AD were randomly divided into two groups, with one group receiving dimethicone and the other receiving the vehicle (cyclomethicone) on selected areas (pinnae, groin, and axillae) daily for 4 weeks. Owners and investigators were blinded to group allocation.Clinical efficacy was evaluated using a scoring system, and skin barrier function was assessed by measuring transepidermal water loss (TEWL). Twelve dogs completed the study, with a 50% drop rate in the vehicle group...

Research Summary: In modern society, people prefer to look well-groomed and presentable. Although this is completely based on individual taste and personality, beauty products greatly help in enhancing external appearance. There are many natural and synthetic cosmetic ingredients in beauty products that provide an aesthetic effect to the individual. As society and science advance, the search for newer cosmetic ingredients continues, offering renewed hope to the growing beauty industry and consumers. Conditioned media has emerged as one of the disruptive innovations of recent times in cosmetic ingredients, providing superior products compared to conventional options. New-generation cosmetic products containing growth factors...

Research Summary: Retinoic acid (RA) is the biologically active metabolite of vitamin A. It is a low molecular weight, lipophilic molecule that acts on the nucleus to induce gene transcription. In amphibians and mammals, it induces the regeneration of several tissues and organs, and these examples are reviewed here. RA induces the "super-regeneration" of organs that can already regenerate, such as the urodele amphibian limb, by respecifying positional information in the limb. In organs that cannot normally regenerate, such as the adult mammalian lung, RA induces the complete regeneration of alveoli that have been destroyed by various noxious treatments. In...

Research Summary: Niacinamide, an amide of vitamin B3 (niacin), is a hydrophilic endogenous substance. Its effects after epicutaneous application have long been described in the literature. Given sufficient bioavailability, niacinamide exhibits antipruritic, antimicrobial, vasoactive, photo-protective, sebostatic, and lightening effects depending on its concentration.Within a complex metabolic system, niacinamide controls the NFκB-mediated transcription of signaling molecules by inhibiting the nuclear poly (ADP-ribose) polymerase-1 (PARP-1). Niacinamide is a well-tolerated and safe substance often used in cosmetics. Clinical data for its therapeutic use in various dermatoses can increasingly be found in the literature. Although the existing data are not sufficient for a scientifically...