Research

Research Summary: It has been recognized that the vehicle in which a permeant is applied to the skin has a distinctive effect on the dermal and transdermal delivery of active ingredients. The cutaneous and percutaneous absorptions can be enhanced, for example, by an increase in thermodynamic activity, supersaturation, and penetration modifiers. Furthermore, dermal and transdermal delivery can be influenced by the interactions that may occur between the vehicle and the skin on the one hand, and interactions between the active ingredient and the skin on the other hand.Emulsions are widely used as cosmetic and pharmaceutical formulations because of their excellent...

Research Summary: Glycerol is a trihydroxy alcohol that has been included for many years in topical dermatological preparations. In addition, endogenous glycerol plays a role in skin hydration, cutaneous elasticity, and epidermal barrier repair. The aquaporin-3 transport channel and lipid metabolism in the pilosebaceous unit have been evidenced as potential pathways for endogenous delivery of glycerol and for its metabolism in the skin. Multiple effects of glycerol on the skin have been reported. The diverse actions of the polyol glycerol on the epidermis include improvement of stratum corneum hydration, skin barrier function, and skin mechanical properties. It also inhibits the...

Research Summary:Background: Nutritional factors play a key role in normal dermatologic functioning. However, little is known about the effects of diet on skin-aging appearance.Objective: We evaluated the associations between nutrient intakes and skin-aging appearance.Design: Using data from the first National Health and Nutrition Examination Survey, we examined associations between nutrient intakes and skin aging in 4025 women aged 40 to 74 years. Nutrients were estimated from a 24-hour recall. Clinical examinations of the skin were conducted by dermatologists. Skin-aging appearance was defined as having a wrinkled appearance, senile dryness, and skin atrophy.Results: Higher vitamin C intakes were associated with a...

Research Summary: Skin aging goes beyond a chronological process and also results from extrinsic factors referred to as the exposome. Hyaluronic acid (HA) is an important component of the extracellular matrix, with loss starting at the age of 25. While many studies of HA focus on its topical use, few literature reviews solely address the use of topical HA in dermatology. This review describes the various characteristics of HA-containing cosmeceuticals, with a focus on skin aging and the impact of exposome factors on HA synthesis and degradation.A review was conducted using terms such as HA, hyaluronan, topical, dermatology, cosmetic, aging...