Research — Safety

Research Summary: Introduction: Ever since the inception of man’s perception towards beauty, there has been a constant inclination toward the care of one’s appearance. The concept of beauty in Ayurveda is present as early as in *Caraka Samhitā* in the form of *varnya dashemani*. Beauty presents a standard of comparison, and it can cause resentment and dissatisfaction when not achieved. For the maintenance of beauty, there has been a dedicated branch of science—cosmetics. However, owing to side effects like allergies, photosensitivity, and even malignancies due to synthetic chemicals, there has been a growing demand for plant-based cosmetics. Aloe vera is...

Research Summary: This study investigated the effects of a skin protectant solution (dimethicone 2%) on clinical signs and skin barrier function in canine atopic dermatitis (AD). Eighteen dogs with AD were randomly divided into two groups, with one group receiving dimethicone and the other receiving the vehicle (cyclomethicone) on selected areas (pinnae, groin, and axillae) daily for 4 weeks. Owners and investigators were blinded to group allocation.Clinical efficacy was evaluated using a scoring system, and skin barrier function was assessed by measuring transepidermal water loss (TEWL). Twelve dogs completed the study, with a 50% drop rate in the vehicle group...

Research Summary: Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods and cosmetics, and as a carrier in PEGylated therapeutics. Even though PEG is thought to be less immunogenic, or perhaps even non-immunogenic, with a variety of physicochemical properties, there is mounting evidence that PEG causes immunogenic responses when conjugated with other materials such as proteins and nanocarriers. Under these conditions, PEG with other materials can result in the production of anti-PEG antibodies after administration.The antibodies that are induced seem to have a deleterious impact on the therapeutic efficacy of subsequently administered PEGylated...

Research Summary: This assessment focuses on polyethylene glycols (PEGs) and on anionic or nonionic PEG derivatives, which are currently used in cosmetics in Europe. These compounds are employed in a variety of cosmetic applications due to their solubility, viscosity properties, and low toxicity. PEGs, their ethers, and their fatty acid esters cause little to no ocular or dermal irritation and exhibit extremely low acute and chronic toxicities. They do not readily penetrate intact skin, and considering the widespread use of preparations containing PEG and PEG derivatives, there have been few reported cases of sensitization reactions. These cases primarily involve patients...