Research — inflammation

Research Summary: Humans are exposed to various external environmental factors, with food intake being one of the most influential factors impacting daily lifestyle. Among the nutrients obtained from foods, omega-3 polyunsaturated fatty acids (PUFAs) have been shown to have various beneficial effects on inflammatory diseases. Furthermore, omega-3 PUFA metabolites, including resolvins, are known to exhibit strong anti-inflammatory effects during allergic and inflammatory diseases. However, little is known about the actual impact of these metabolites on skin diseases.In this review, we focused on metabolites that have strong anti-inflammatory actions in various inflammatory diseases, as well as those that present antitumor actions...

Research Summary: It is estimated that total sun exposure occurs non-intentionally in three quarters of our lifetimes. Our skin is exposed to the majority of UV radiation during outdoor activities, such as walking, practicing sports, running, hiking, etc., and not when we are intentionally exposed to the sun on the beach. We rarely use sunscreens during those activities, or at least not as much and as regularly as we should, making us commonly prone to acute and chronic sun damage of the skin. The only protection of our skin is endogenous (synthesis of melanin and enzymatic antioxidants) and exogenous (antioxidants,...

Research Summary: α-(-)-bisabolol, a natural monocyclic sesquiterpene found in essential oils, has garnered significant interest in the chemical and pharmaceutical industries and is currently utilized in various formulations, particularly in cosmetics. This study aimed to evaluate its therapeutic potential against skin inflammation using in-vitro, in-vivo, and in-silico assays.Lipopolysaccharide (LPS) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced production of pro-inflammatory cytokines (TNF-α and IL-6) in macrophage cells, as well as TPA-induced skin inflammation in mice, were significantly inhibited by α-(-)-bisabolol. Furthermore, TPA-induced ear thickness, ear weight, lipid peroxidation, and histopathological damage in ear tissue were also significantly reduced by the topical application of α-(-)-bisabolol in...

Research Summary: Omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) are nowadays desirable components of oils with special dietary and functional properties. Their therapeutic and health-promoting effects have already been established in various chronic inflammatory and autoimmune diseases through various mechanisms, including modifications in cell membrane lipid composition, gene expression, cellular metabolism, and signal transduction.The application of ω-3 and ω-6 PUFAs in the most common skin diseases has been examined in numerous studies, but their results and conclusions were mostly opposing and inconclusive. It seems that combined ω-6, gamma-linolenic acid (GLA), and ω-3 long-chain PUFAs supplementation exhibits the highest...