Research — Biochemistry

Human skin is exposed daily to various environmental factors, including air pollutants and ultraviolet (UV) light. Air pollution is recognized as a significant environmental risk to human skin, promoting aging and inflammation that lead to skin disorders, wrinkles, and pigmentation issues. Moreover, components of air pollution can synergize with UV light, amplifying skin damage. Despite this, the role of air pollution in modulating cellular senescence in skin cells and its contribution to skin aging remains poorly understood. This review summarizes the current knowledge on air pollution components, their role in cellular senescence and skin aging, and the therapeutic and cosmetic...

The increase in air pollution over the years has significantly impacted human skin. The skin is exposed to ultraviolet radiation (UVR) and environmental air pollutants such as polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds (VOCs), oxides, particulate matter (PM), ozone (O₃), and cigarette smoke. Although human skin functions as a biological shield against pro-oxidative chemical and physical air pollutants, prolonged or repetitive exposure to high levels of these pollutants can have profound negative effects. Such exposure has been linked to skin aging, as well as inflammatory and allergic skin conditions, including atopic dermatitis, eczema, psoriasis, and acne. Among the most...

Research Summary: The role of cosmetic products is rapidly evolving in our society, with their use increasingly seen as an essential contribution to personal wellness. This suggests the necessity of a detailed elucidation of the use of nanoparticles (NPs) in cosmetics. The aim of the present work is to offer a critical and comprehensive review discussing the impact of exploiting nanomaterials in advanced cosmetic formulations, emphasizing the beneficial effects of their extensive use in next-generation products despite a persisting prejudice around the application of nanotechnology in cosmetics. The discussion here includes an interpretation of the data underlying generic information reported...

Research Summary: Stem cells are precursor cells present in many tissues with the ability to differentiate into various types of cells. This interesting property of plasticity can have therapeutic implications, and there has been substantial research in this field over the last few decades. As a result, stem cell therapy is now used as a therapeutic modality in many conditions, and it has made its way into dermatology as well. Stem cells can be classified based on their source and differentiating capacity. In the skin, they are present in the inter-follicular epidermis, hair follicle, dermis, and adipose tissue, helping to...