notizie-1

Research Summary: The main function of the epidermis is to generate an impermeable outer layer, the stratum corneum. The stratum corneum can be considered morphologically and functionally as a two-compartment system composed of: 1) anucleate corneocytes (the bricks), largely made up of fibrous protein networks, and 2) the intercellular matrix (the mortar), predominantly composed of neutral lipids. Whereas much of the prior and current research on the stratum corneum has focused on the protein biochemistry leading to the formation of the keratinized corneocyte (“keratinization”), this paper is concerned with the formation, composition, and function of the intercellular matrix of the...

Research Summary: α-(-)-bisabolol, a natural monocyclic sesquiterpene found in essential oils, has garnered significant interest in the chemical and pharmaceutical industries and is currently utilized in various formulations, particularly in cosmetics. This study aimed to evaluate its therapeutic potential against skin inflammation using in-vitro, in-vivo, and in-silico assays.Lipopolysaccharide (LPS) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced production of pro-inflammatory cytokines (TNF-α and IL-6) in macrophage cells, as well as TPA-induced skin inflammation in mice, were significantly inhibited by α-(-)-bisabolol. Furthermore, TPA-induced ear thickness, ear weight, lipid peroxidation, and histopathological damage in ear tissue were also significantly reduced by the topical application of α-(-)-bisabolol in...

Research Summary: Cyclic and linear siloxanes are compounds synthesized from silicon, consisting of alternating atoms of silicone and oxygen [Si-O] units with organic side chains. The most common cyclic siloxanes are octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and dodecamethylcyclohexasiloxane (D6), while the most common linear siloxanes are high molecular weight polydimethylsiloxanes (PDMS) and low molecular weight volatile linear siloxanes known as hexamethyldisiloxane (L2), octamethyltrisiloxane (L3), decamethyltetrasiloxane (L4), and dodecamethylpentasiloxane (L5). These compounds exhibit low dermal toxicity, are generally inert and non-reactive, and are compatible with a wide range of chemicals. They offer beneficial properties such as wash-off or transfer resistance from the...

Research Summary: Enclosed is the Draft Report on the Safety Assessment of Polysilicone-11 as Used in Cosmetics (polysil122019rep). This ingredient is a crosslinked dimethylsiloxane, formed by the reaction of bis-vinyldimethicone and hydrogen dimethicone, and is reported to function as a film former in cosmetics.Following an intensive search of information in the published scientific literature, online databases, and other sources on this ingredient, there was insufficient information found to justify the preparation of a formal Scientific Literature Review (SLR). Therefore, in July 2019, CIR issued a SLR Notice to Proceed (NTP) for Polysilicone-11 to alert interested parties that a safety assessment...