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Research Summary Local delivery of drugs is a promising strategy for managing periodontitis, which is characterized by chronic inflammation of the soft tissue surrounding the teeth. An optimized system should prolong drug retention time and exhibit controlled drug permeation through the buccal mucosal layer. This study aimed to develop a hydroxyethyl cellulose (HEC)-based gel containing metronidazole (MTZ) loaded in solid lipid nanoparticles (SLNs) to enhance the antimicrobial activity of MTZ.SLNs were prepared using a combination of solvent evaporation and hot homogenization methods. The results showed that the fabricated SLNs, comprising Precirol (2.93%, w/v), Tween 80 (1.8%, w/v), and a drug-to-lipid...

Research Summary The use of aloe vera is being promoted for a wide variety of conditions. The aim of this review was to summarize all available research papers on aloe vera preparations to provide evidence for or against its clinical effectiveness.Independent literature searches were conducted in PubMed. All studies of controlled clinical trials, observational studies, and case series were included, with no restrictions on the language of publication. All studies were reviewed by all authors, and data were extracted in a standardized, pre-defined manner.Although there are some promising results, the clinical effectiveness of oral or topical aloe vera is not...

Research SummaryIn recent years, many studies have found that vitamin K is beneficial for wound healing. However, some research results appear to be in conflict. The purpose of this study was to evaluate the effect of vitamin K on wound healing.Methods:We systematically and comprehensively searched the PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, and Wanfang electronic databases. RevMan 5.3 software was used to calculate the weighted mean difference (WMD) of 95% confidence interval (CI) for animal and cell groups to evaluate the effect of vitamin K on wound healing. Two researchers independently selected studies...

Research Summary Non-invasive methods to evaluate skin hydration by measuring electrical properties are widely used in the cosmetic industry. However, there is still some controversy about factors that affect these measurements. For example, concerns have often been expressed about the possible confounding effect of salts, either in the formulation or on the skin. Ionized salts on the skin may increase electrical conductivity and lead to changes in electrical properties that are not related to increased water content.We have conducted a systematic study to investigate the effects of salt, specifically sodium chloride, and glycerin on the electrical properties of skin as...