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Research Summary Glycerol is a trihydroxy alcohol that has been used for many years in topical dermatological preparations. In addition, endogenous glycerol plays a role in skin hydration, cutaneous elasticity, and epidermal barrier repair. The aquaporin-3 transport channel and lipid metabolism in the pilosebaceous unit have been identified as potential pathways for endogenous delivery of glycerol and its metabolism in the skin.Multiple effects of glycerol on the skin have been reported. The diverse actions of the polyol glycerol on the epidermis include improvement of stratum corneum hydration, skin barrier function, and skin mechanical properties. It also inhibits the stratum corneum...

Research Summary Moisturizing products are commonly used to improve hydration in skin dryness conditions. However, some topical hydrating products can have negative effects on skin barrier function. In addition, the hydrating effects of moisturizers are not typically evaluated up to 24 hours after a single application. Hyaluronic acid (HA) and glycerin are well-known substances that improve skin hydration. Centella asiatica extract (CAE) may exert lenitive, anti-inflammatory, and reepithelialization actions. Furthermore, CAE could inhibit hyaluronidase enzyme activity, thereby prolonging the effect of HA. A fluid containing 1% HA, 5% glycerin, and stem cells from CAE has recently been developed, known as...

Research Summary GHK (glycyl-L-histidyl-L-lysine) is a naturally occurring peptide found in human plasma, saliva, and urine, but its levels decline with age. It is proposed that GHK functions as a complex with copper 2+, which accelerates wound healing and skin repair. GHK plays a dual role, stimulating both the synthesis and breakdown of collagen and glycosaminoglycans. It also modulates the activity of metalloproteinases and their inhibitors. This molecule is involved in stimulating the production of collagen, dermatan sulfate, chondroitin sulfate, and the small proteoglycan decorin, which are essential for skin structure and repair.In addition to its effects on collagen, GHK...

Research Summary Acne is an inflammatory skin condition that develops in pilosebaceous follicles, primarily affecting individuals during the onset of puberty. Among the numerous chemicals with dermatological and cosmetic purposes, raw materials of mineral origin have often been sought in formulations aimed at treating and preventing acne. This study aimed to develop cosmetic preparations including green clay and to conduct sensory analysis of these formulations.Four formulations containing 2.5% to 5% green clay, in the presence or absence of dimethicone, were prepared. The rheological behavior of the samples was analyzed at various time intervals—0, 24 hours, 30 days, 60 days, and...