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Research Summary Vitamin E, a name given to a series of related tocopherols with similar biological effects, has been advocated as a stimulant to healing. Unfortunately, no controlled studies have been conducted to substantiate this claim. Based on the findings of Lucy and Dingle, Vitamin E is now understood to be a lysosomal stabilizer. This places it in a category of compounds, such as glucocorticoids and aspirin, which are known to be anti-inflammatory agents and inhibitors of healing.On the other hand, lysosomal-labilizing compounds, such as Vitamin A, digitonin, testosterone, and papain, have been found to stimulate collagen synthesis and repair....

Research Summary Scientific and commercial interest in probiotics, prebiotics, and their effect on human health and disease has increased significantly over the last decade. This review article aims to evaluate the role of probiotics and prebiotics on the normal function of healthy skin, as well as their role in the prevention and therapy of skin diseases. Lactobacilli and Bifidobacterium are the most commonly used probiotics and are thought to mediate skin inflammation, treat atopic dermatitis (AD), and prevent allergic contact dermatitis (ACD). Probiotics have been shown to decolonize skin pathogens, such as *P. aeruginosa*, *S. aureus*, and *A. Vulgaris*. Additionally,...

Research Summary Human skin is a complex ecosystem and is host to a large number of microorganisms. When the bacterial ecosystem is balanced and differentiated, the skin remains healthy. However, the use of cosmetics can alter this balance and promote the appearance of skin diseases. Some microorganisms on the skin can utilize certain cosmetic components, which either promote their growth or produce metabolites that influence the skin environment.In this study, we tested the ability of the *Malassezia* species and some bacterial strains to assimilate substances frequently used in dermal formulations. The growth capability of microorganisms was determined, and their lipase...

Research Summary Juvéderm® HYDRATE is a new un-crosslinked hyaluronic acid (HA) injectable treatment containing mannitol. It comprises 13.5 mg/g of un-crosslinked hyaluronic acid along with 0.9% mannitol. This treatment is indicated for improving skin hydration and elasticity through multi-injection techniques into the dermal/epidermal junction and the superficial dermis. The purpose is to enhance skin tone and reduce the appearance of fine lines and wrinkles.The inclusion of mannitol in the formulation helps reduce free radical degradation of the hyaluronic acid, thereby extending its longevity. <Access the full report below>