notizie-1 — Protection

Research Summary One of the main functions of cutaneous tissues is to protect our body from outdoor insults. Ozone (O3) is among the most toxic stressors to which we are continuously exposed, and due to its critical location, the skin is one of the most susceptible tissues to the oxidative damaging effects of O3. While O3 is not able to penetrate the skin, and is not a radical per se, the damage is mainly a result of its ability to induce oxidative stress via the formation of lipid peroxidation products.Aim of StudyIn this study, we investigated the protective effect of...

Research Summary Sun protection products have been used to mitigate the harmful effects of Ultra Violet (UV) sun rays for centuries. These products protect against sunlight-induced erythema, with their level of performance indicated by the sun protection factor (SPF). The present investigation was conducted with the aim of determining the effect of different concentrations of titanium dioxide on SPF using mice as test subjects.In this study, the mice were divided into four groups. Group I served as the control, while Groups II and III served as test groups, treated with formulations containing 10% and 20% titanium dioxide, respectively. All the...

Research Summary: This assessment focuses on polyethylene glycols (PEGs) and on anionic or nonionic PEG derivatives, which are currently used in cosmetics in Europe. These compounds are employed in a variety of cosmetic applications due to their solubility, viscosity properties, and low toxicity. PEGs, their ethers, and their fatty acid esters cause little to no ocular or dermal irritation and exhibit extremely low acute and chronic toxicities. They do not readily penetrate intact skin, and considering the widespread use of preparations containing PEG and PEG derivatives, there have been few reported cases of sensitization reactions. These cases primarily involve patients...

Research Summary: Witch hazel extracts have been used for decades as cosmetic ingredients in skin care products. Our present study aims to evaluate its potential in anti-pollution products using a previously reported in vitro model. Calcium is a universal second messenger, and we used human respiratory and skin cells to detect changes in intracellular Ca2+ concentrations upon particulate matter contact. Both an increase in pro-inflammatory markers and a decrease in tight junction proteins were confirmed, as previously reported. Witch hazel stem and leaf extract showed significant attenuation of Ca2+ response upon the challenge; it displayed systematic regulations of the signal...