Research Summary:
Skin aging has become a recurring concern even for younger people, primarily due to increased life expectancy. In this context, the use of nutricosmetics as supplements has gained popularity in recent years. Numerous scientific studies have demonstrated the benefits of hydrolyzed collagen supplementation in improving the signs of skin aging. The objective of this study was to summarize the evidence on the effects of hydrolyzed collagen supplementation on human skin through a systematic review followed by a meta-analysis of clinical trials, focusing on the process of skin aging.
A literature search was conducted in the Medline, Embase, Cochrane, LILACS (Latin American and Caribbean Health Sciences Literature), and Journal of Negative Results in BioMedicine databases. Eligible studies were randomized, double-blind, and controlled trials that evaluated oral supplementation with hydrolyzed collagen as an intervention and reported at least one of the following outcomes: skin wrinkles, hydration, elasticity, and firmness.
After retrieving articles from the databases, 19 studies were selected, with a total of 1,125 participants aged between 20 and 70 years (95% women). In the meta-analysis, a grouped analysis of studies showed favorable results for hydrolyzed collagen supplementation compared with placebo, particularly in terms of skin hydration, elasticity, and wrinkles. The findings of improved hydration and elasticity were also confirmed in the subgroup meta-analysis. Based on the results, the ingestion of hydrolyzed collagen for 90 days is effective in reducing skin aging, as it decreases wrinkles and improves skin elasticity and hydration.
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