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Research Summary To identify the available evidence in the literature on the topical effect of *Chamomilla recutita* to prevent and/or treat skin damage, a literature review was conducted using the following bibliographic databases: The Cochrane Library, PubMed, LILACS, CINAHL, and Web of Science. A total of 11 comparative clinical studies utilized chamomile for different skin conditions, including erythema, pityriasis alba, eczema-like lesions, peristomal injury, contact dermatitis, phlebitis, atopic eczema, radiodermatitis, induced contact dermatitis, wound healing, and eczema.The review highlights the need to develop more comparative clinical studies that test standardized formulas, with outcomes measured using validated scales. This would encourage...

Background: The anatomic layers of the skin are well-defined, and a functional model of the skin barrier has recently been described. Barrier disruption plays a key role in several skin conditions, and moisturization is recommended as an initial treatment in conditions such as atopic dermatitis. This review aimed to analyze the skin barrier in the context of the function model, with a focus on the mechanisms by which moisturizers support each of the functional layers of the skin barrier to promote homeostasis and repair.Summary: The skin barrier is comprised of four interdependent layers – physical, chemical, microbiologic, and immunologic –...

Background: Bone tissue engineering and research on peptides have significantly expanded over the last few decades. Several peptides have been shown to support and stimulate the bone healing response and have been proposed as therapeutic vehicles for clinical use. The aim of this comprehensive review is to present the clinical and experimental studies analyzing the potential role of peptides for bone healing and bone regeneration.Methods: A systematic review following PRISMA guidelines was conducted. Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study.Results: Based on the available literature, there is...

Research Summary Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are increasing year by year. AIDs occur when the immune system misidentifies self-antigens, which appears to be caused by excessive immune function. In reality, it is the result of reduced accuracy in the immune system's ability to differentiate between foreign invaders and self-antigens. This decline in immune system function leads to false attacks on the body, eventually resulting in disease.The occurrence of AIDs is often accompanied by the emergence of inflammation. Inflammatory mediators, such as inflammatory factors and inflammasomes, play a critical role in the pathogenesis of AIDs....