nouvelles-1 — aging

Research Summary: This study aims to evaluate the skin moisturizing efficacy of formulations containing different concentrations of panthenol. Formulations supplemented with or without 0.5%, 1.0%, or 5.0% panthenol were applied daily to the forearms of healthy subjects. Skin conditions in terms of moisture and transepidermal water loss (TEWL) were analyzed before and after 15- and 30-day periods of application. The formulations were also applied after skin washing with sodium laureth sulphate (SLES) to evaluate the immediate effects on TEWL and skin moisture. Panthenol-containing formulations (1.0% and 5.0%) produced significant decreases in TEWL after 30-day applications. In skin washed with SLES,...

Research Summary Vitamin C in humans must be ingested for survival. As an electron donor, vitamin C acts as a potent water-soluble antioxidant. This property underlies all of its known functions. The antioxidant effects of vitamin C have been demonstrated in numerous in vitro experiments. Human diseases such as atherosclerosis and cancer might partially result from oxidant damage to tissues. Oxidation of lipids, proteins, and DNA leads to specific oxidation products that can be measured in laboratory settings. While these biomarkers of oxidation have been measured in humans, the assays used are neither validated nor standardized, and the connection between...

Research Summary Sun protection products have been used to mitigate the harmful effects of Ultra Violet (UV) sun rays for centuries. These products protect against sunlight-induced erythema, with their level of performance indicated by the sun protection factor (SPF). The present investigation was conducted with the aim of determining the effect of different concentrations of titanium dioxide on SPF using mice as test subjects.In this study, the mice were divided into four groups. Group I served as the control, while Groups II and III served as test groups, treated with formulations containing 10% and 20% titanium dioxide, respectively. All the...

Vitamin B3 (nicotinic acid, niacin) deficiency causes the systemic disease pellagra, which leads to dermatitis, diarrhea, dementia, and possibly death, depending on its severity and duration. Vitamin B3 is used in the synthesis of the NAD+ family of coenzymes, contributing to cellular energy metabolism and defense systems. Although nicotinamide (niacinamide) is primarily used as a nutritional supplement for vitamin B3, its pharmaceutical and cosmeceutical uses have been extensively explored.In this review, we discuss the biological activities and cosmeceutical properties of nicotinamide in consideration of its metabolic pathways. Supplementation of nicotinamide restores the cellular NAD+ pool and mitochondrial energetics, attenuates oxidative...