Research Summary
Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are increasing year by year. AIDs occur when the immune system misidentifies self-antigens, which appears to be caused by excessive immune function. In reality, it is the result of reduced accuracy in the immune system's ability to differentiate between foreign invaders and self-antigens. This decline in immune system function leads to false attacks on the body, eventually resulting in disease.
The occurrence of AIDs is often accompanied by the emergence of inflammation. Inflammatory mediators, such as inflammatory factors and inflammasomes, play a critical role in the pathogenesis of AIDs. These mediators affect both innate immune cells, such as macrophages, and adaptive immune cells, such as T and B cells, thereby promoting autoimmune responses. As a result, targeting inflammatory mediators and pathways has become an emerging treatment strategy for AIDs.
This review will briefly describe the role of inflammation in the pathogenesis of various AIDs and provide an overview of inhibitors targeting inflammatory factors. The hope is that this information will serve as a reference for future treatment options for autoimmune diseases.
Keywords: autoimmunity, inflammation, pro-inflammatory factors, T cells, B cells
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