notizie-1 — Cell activation

Research Summary: Stem cells are precursor cells present in many tissues with the ability to differentiate into various types of cells. This interesting property of plasticity can have therapeutic implications, and there has been substantial research in this field over the last few decades. As a result, stem cell therapy is now used as a therapeutic modality in many conditions, and it has made its way into dermatology as well. Stem cells can be classified based on their source and differentiating capacity. In the skin, they are present in the inter-follicular epidermis, hair follicle, dermis, and adipose tissue, helping to...

Research Summary: In modern society, people prefer to look well-groomed and presentable. Although this is completely based on individual taste and personality, beauty products greatly help in enhancing external appearance. There are many natural and synthetic cosmetic ingredients in beauty products that provide an aesthetic effect to the individual. As society and science advance, the search for newer cosmetic ingredients continues, offering renewed hope to the growing beauty industry and consumers. Conditioned media has emerged as one of the disruptive innovations of recent times in cosmetic ingredients, providing superior products compared to conventional options. New-generation cosmetic products containing growth factors...

Research Summary: Retinoic acid (RA) is the biologically active metabolite of vitamin A. It is a low molecular weight, lipophilic molecule that acts on the nucleus to induce gene transcription. In amphibians and mammals, it induces the regeneration of several tissues and organs, and these examples are reviewed here. RA induces the "super-regeneration" of organs that can already regenerate, such as the urodele amphibian limb, by respecifying positional information in the limb. In organs that cannot normally regenerate, such as the adult mammalian lung, RA induces the complete regeneration of alveoli that have been destroyed by various noxious treatments. In...

Research Summary: The skin is a vital organ, serving as the body’s largest barrier, but its function declines with aging. As a result, research into effective regeneration treatments must continue to advance. Stem cell transplantation, a cell-based therapy, has become a popular treatment for skin aging, although it comes with drawbacks such as host immune reactions. To address this, stem cell-derived cell-free therapies have emerged as an alternative, backed by promising preclinical findings. The key components in cell-free therapy from stem cells are stem cell secretomes and extracellular vesicles (EVs). However, comprehensive reviews on the mechanisms of such treatments for...