Research Summary
Millions of people around the world, aged 35 and above, experience fluctuating lifestyles, increased exposure to blue light, and the effects of a faster-depleting ozone layer. This enhances the penetration of UVA and UVB rays into the skin, accelerating the aging process, leading to collagen degradation, fine lines, and decreased cell senescence. The primary goal of skin rejuvenation is to maintain healthy skin. In recent years, cosmeceuticals incorporating retinoids have been increasingly used to promote collagen synthesis and rejuvenate the skin.
Both photo-induced and chronological aging processes are slowed with the application of retinoids, which help to improve skin elasticity by neutralizing free radicals, promoting new cell growth, and enhancing blood vessel formation within the skin. This helps fight pigmentation and reduce fine lines. Retinoids are commercially available as creams and serums for topical application. To improve stability, efficacy, and acceptability, nanotechnology has been employed in the development of retinoids, minimizing adverse reactions like skin irritation and purging.
Emerging studies on retinoids include formulating them within liposomes, solid lipid nanoparticles, nano-emulgels, and hydrogels. This review delves into understanding the aging process, the mechanism of action of retinoids in combating aging, and the potential use of nanotechnological delivery systems in cosmeceuticals.
Keywords: Photoaging, topical systems, retinol, nanoparticles, nano-drug delivery, liposomes.
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