Research Summary
The skin is the most extensive and abundant tissue in the human body. Like many organs, human skin experiences gradual atrophy in both the epidermis and dermis as we age. This process can primarily be attributed to the diminishing population of epidermal stem cells and the reduction in collagen, which is the primary structural protein in the human body. The alterations occurring in the epidermis and dermis due to aging result in disruptions to the structure and functionality of the skin.
These changes create a microenvironment conducive to age-related skin conditions, such as a compromised skin barrier, slowed wound healing, and the onset of skin cancer. This review emphasizes recent molecular discoveries related to skin aging and evaluates preventive approaches, particularly the use of topical retinoids. Topical retinoids have shown promise in enhancing skin texture, diminishing fine lines, and increasing the thickness of both the epidermal and dermal layers.
Keywords: skin aging, retinol, collagen, MMPs, TGF-β.
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