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Research Summary Many people have always aspired to have skin that is young-looking and vibrant. The natural aging process of the skin, which is impacted by both internal and external factors, has sparked further research into its origins and the creation of efficient therapeutic approaches. This review aims to give a thorough understanding of the skin's composition, the causes and variables that contribute to skin aging, the difficulties in treating skin aging, and the methods used to treat skin aging.It will also go into detail about the obstacles antioxidants face while trying to permeate the skin and their potential role...

Research Summary Enclosed is the Draft Report on the Safety Assessment of Charcoal Ingredients as Used in Cosmetics. (It is identified as report_Charcoal_092023 in the PDF document). The Scientific Literature Review (SLR) of four ingredients—Charcoal, Charcoal Extract, Charcoal Powder, and Activated Charcoal—was issued by CIR on April 18, 2023. Although Activated Charcoal is not currently listed in the Dictionary, it is reported to be in use according to both the FDA VCRP database for frequency of use and the concentration of use survey conducted by the Council.According to 2023 VCRP survey data, Charcoal Powder has the highest frequency of use,...

Research Summary The use of sunscreen products has been advocated by many health care practitioners as a means to reduce skin damage produced by ultraviolet radiation (UVR) from sunlight. There is a need to better understand the efficacy and safety of sunscreen products given this ongoing campaign encouraging their use. The approach used to establish sunscreen efficacy, sun protection factor (SPF), is a useful assessment of primarily UVB (290-320 nm) filters. However, the SPF test does not adequately assess the complete photoprotective profile of sunscreens, specifically against long wavelength UVA1 (340-400 nm). Moreover, to date, there is no singular, agreed-upon...

Research Summary Niacinamide (also known as nicotinamide, 3-pyridinecarboxamide) is the physiologically active form of niacin or vitamin B3, the deficiency of which results in the nutritional disease pellagra with distinct cutaneous manifestations. Since its discovery and isolation, a host of dermatological therapeutic benefits and mechanisms have also been ascribed to this essential water-soluble vitamin when used as a topical agent.These include its apparent role as an anti-acne active, an up-regulator of epidermal sphingolipid synthesis, and an up-regulator of markers of epidermal differentiation and dermal proliferation, with concurrent stratum corneum barrier benefits. Niacinamide also acts as a moderator of photoimmunesuppression and...