Research Summary
Caprylyl glycol and related 1,2-glycols are primarily used as skin and hair conditioning agents, as well as viscosity agents in cosmetic products. In addition to these functions, caprylyl glycol and pentylene glycol also serve as cosmetic preservatives. The Cosmetic Ingredient Review (CIR) Expert Panel acknowledged that while these ingredients are absorbed through the skin, modeling data suggested a decrease in skin penetration with longer-chain 1,2-glycols.
The negative oral toxicity data on shorter-chain 1,2-glycols, along with supportive genotoxicity data, further reinforce the safety of the 1,2-glycols evaluated in this safety assessment. As a result, the Panel concluded that these ingredients are safe for use in the present practices of application and concentration described in the assessment.
Keywords: 1,2-glycols.
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