Research Summary:
To review the composition, actions, and clinical applications of the *Aloe vera* plant in dentistry and to establish its effectiveness as an invaluable adjunct in the treatment of dental diseases.
Method. A manual and electronic literature (MEDLINE, Cochrane Central Register of Controlled Trials, and Google Scholar) search was performed up to July 2013 for in vitro and in vivo studies and research presenting clinical, microbiological, immunological, and patient-centered data to validate the efficacy of Aloe vera gel in dentistry. A total of 38 titles, abstracts, and full-text studies were selected and reviewed.
Aloe vera has various medicinal properties such as anti-inflammatory, antibacterial, antiviral, and antitumor effects, which accelerate wound healing and help in treating various lesions in the oral cavity. The benefits associated with Aloe vera have been attributed to the polysaccharides contained in the gel of the leaves.
Conclusion: The pharmacological attributes of Aloe vera have been revalidated in modern sciences through various in vivo and in vitro studies. The herb has immense potential as a dental therapeutic. Even though Aloe vera is a promising herb with various clinical applications in medicine and dentistry, more clinical research needs to be undertaken, especially to validate and explain the action of acemannan hydrogel in accelerating the healing of aphthous ulcers and to validate the efficacy of *Aloe* gel on plaque and gingivitis, so that it can be established in the field of dentistry.
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