Research Summary:
Humans are exposed to various external environmental factors, with food intake being one of the most influential factors impacting daily lifestyle. Among the nutrients obtained from foods, omega-3 polyunsaturated fatty acids (PUFAs) have been shown to have various beneficial effects on inflammatory diseases. Furthermore, omega-3 PUFA metabolites, including resolvins, are known to exhibit strong anti-inflammatory effects during allergic and inflammatory diseases. However, little is known about the actual impact of these metabolites on skin diseases.
In this review, we focused on metabolites that have strong anti-inflammatory actions in various inflammatory diseases, as well as those that present antitumor actions in malignancies. We also explored the actual effects of omega-3 PUFA metabolites on various cells.
Keywords: w3 polyunsaturated fatty acids, resolvin, protectin, maresin, metabolites.
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