Research Summary:
Glycerol is a trihydroxy alcohol that has been included for many years in topical dermatological preparations. In addition, endogenous glycerol plays a role in skin hydration, cutaneous elasticity, and epidermal barrier repair. The aquaporin-3 transport channel and lipid metabolism in the pilosebaceous unit have been evidenced as potential pathways for endogenous delivery of glycerol and for its metabolism in the skin.
Multiple effects of glycerol on the skin have been reported. The diverse actions of the polyol glycerol on the epidermis include improvement of stratum corneum hydration, skin barrier function, and skin mechanical properties. Glycerol also inhibits the stratum corneum lipid phase transition, protects against irritating stimuli, enhances desmosomal degradation, and accelerates wound-healing processes. Even an antimicrobial effect has been demonstrated.
Topical application of glycerol-containing products improves skin properties in diseases characterized by xerosis and impaired epidermal barrier function, such as atopic dermatitis. The increase of epidermal hydration by glycerol is critical in skin conditions aggravated by dry and cold environmental conditions, e.g., winter xerosis.
This paper provides a review of the effects of glycerol on the skin, the mechanisms of its action, and the potential applications of glycerol in dermatology.
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Key words
epidermal barrier, hydration, irritation, moisturization, wound healing