Research Summary
New methods to protect the skin from photodamage caused by sun exposure are essential if we are to combat skin cancer and photoaging. While sunscreens are helpful, their protection is not ideal due to inadequate use, incomplete spectral coverage, and concerns about toxicity. The skin naturally employs antioxidants (AOs) to defend itself against photodamage. This scientific review summarizes current knowledge about how photodamage occurs, why sunscreens—the current gold standard for photoprotection—are insufficient, and how topical antioxidants can help protect against skin cancer and photoaging.
This review serves as a reference source, including comprehensive reviews when available. Although not all antioxidants are discussed, an effort has been made to select those for which enough information is available to support their potential topical uses and benefits. The following physiological and plant-based antioxidants are reviewed: vitamin C, vitamin E, selenium, zinc, silymarin, soy isoflavones, and tea polyphenols. The topical use of these antioxidants may enhance sunscreen protection and provide additional anticarcinogenic benefits.
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