Research Summary
Retinoids are a group of substances that include vitamin A and its natural and synthetic derivatives. Retinoids were first introduced in dermatology in 1943 by Straumfjord for the treatment of acne vulgaris. Since then, retinoids have been widely used in the management and treatment of various skin conditions, including photoaging.
Photodamage to the skin occurs as a result of cumulative exposure to solar ultraviolet radiation (UVR) and is characterized by deep wrinkles, easy bruising, inelasticity, mottled pigmentation, roughness, and telangiectasias. The mechanism behind UVR-induced photodamage is multifactorial. Retinoids have shown efficacy in treating photoaged skin, making them a valuable tool in dermatology.
Understanding the pathophysiology of photoaging and the molecular mechanism of retinoids not only sheds light on their effectiveness in treating photoaging but also provides the rationale for their use in treating other dermatologic diseases.
Key words:
- Vitamin A and its derivatives play a role in the treatment of photoaging.
- Topical retinoids are safe and effective in managing and treating photodamaged skin.
- Further understanding of skin aging and retinoids may open opportunities for developing new therapeutic options.
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