Research Summary
The delivery of medications through the skin has long been a fascinating yet challenging subject of study. For various medications, topical drug administration has offered significant advantages over the systemic route, one of the most important being reduced toxicity due to minimal or no exposure to non-target organs. Because of its simplicity and affordability, topical administration is the preferred method for delivering medicinal substances locally.
The topical drug delivery system includes solid powders, semisolids, liquid preparations, and sprays, among other pharmaceutical dosage forms. Gels, creams, and ointments are the most commonly used semisolid preparations for topical medication delivery. These methods allow a drug to penetrate the epidermal layer and enter the systemic circulation at a controlled rate.
In addition to existing formulations, new drugs are being developed utilizing the transdermal approach due to the inherent benefits of delivery via this route. Although low skin permeability limits its broader applicability, it still provides a non-invasive route for medication administration. Innovative research using penetration-enhancing technologies such as iontophoresis, electroporation, microneedles, sonophoresis, and others shows promise for successful implementation of these drugs in clinical practice as consumer-friendly, transdermal dosage forms.
This paper examines some of the most promising new strategies for enhancing transdermal permeability, while also providing a scientific update on recent advancements in topical drug delivery systems. The current study focuses on the latest methods and techniques for administering local treatment to the skin. This information serves as a foundation for further research and development of existing methodologies and technologies.
Keywords: Topical drug delivery, Recent techniques, TDDS, Advances in skin delivery
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