Research Summary
As the population ages, common skin disorders among the elderly require increasing attention. Additionally, the clinical, histologic, and physiological changes that characterize aging skin are becoming more closely linked to its vulnerability to environmental injuries and certain diseases. This growing concern emphasizes the need for dermatologists to explore the biological aging process in the skin, as well as the distinct process of photoaging, which has become a significant clinical issue.
Current studies at the cellular level have revealed substantial functional losses, especially in proliferative capacity, from infancy to adulthood. These losses are even more pronounced as individuals transition from early to late adulthood, particularly as a result of chronic sun exposure. Ongoing, careful, and quantitative assessments of aging and photoaging in human skin, both in vivo and in vitro, are essential for a deeper understanding of these processes and, importantly, for achieving successful therapeutic interventions.
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