Research Summary
Disruption of the skin barrier and immunity has been associated with several skin diseases, namely atopic dermatitis (AD), psoriasis, and acne. Resident and non-resident immune cells, along with the barrier system of the skin, are integral to innate immunity.
Recent advances in understanding skin microbiota have opened avenues for further exploration of the various communications between these microbiota and skin immune cells. Vitamins, being essential micronutrients, have been reported to exert antioxidant, anti-inflammatory, and anti-microbial effects. The immunomodulatory action of vitamins can halt the progression of skin diseases. Thus, understanding the immuno-pharmacology of these vitamins—especially for skin diseases—can pave the way for their therapeutic potential.
At the same time, molecular and cellular markers modulated by these vitamins and their derivatives need to be explored. The present review focuses on significant vitamins (A, B3, C, D, and E) consumed as nutritional supplements, discussing the outcomes and scope of studies related to skin immunity, health, and diseases.
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